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    DECIPHERING THE IMPORTANCE OF NANOENCAPSULATION TO IMPROVE THE AVAILABILITY OF BIOACTIVE MOLECULES IN FOOD SOURCES TO THE HUMAN BODY
    (Elsevier Ltd, 2025-02) Arivalagan Pugazhendhi; Mohammed Ali Alshehri; Sabariswaran Kandasamy; Prakash Kumar Sarangi; Ashutosh Sharma; Department of Biotechnology; Sabariswaran Kandasamy
    Various bodily functions are maintained, and health benefits are provided by food-derived bioactive components. Fruits and vegetables contain numerous beneficial components, including vitamins, minerals, antioxidants, enzymes, and phytonutrients. However, the body's ability to absorb these substances at a given rate and degree frequently limits their bioavailability. If food-derived bio actives are used as therapeutic or dietary interventions, this limitation can result in low efficacy and suboptimal results. Recently, nanotechnology has been a useful method for increasing the bioavailability of bioactive compounds produced from food. Active ingredients can be delivered and absorbed more efficiently with the help of nanotechnology. By altering their size or surface properties, bioactive components can be made more soluble, permeable, and bioavailable through nanotechnology. The present review will provide an overview of the various bioactive components, the application of nanotechnology to improve the availability of bioactive molecules to humans and animals, and the challenges and safety concerns associated with nanotechnology in the production of food-derived bioactive molecules.
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    EXPLORING QUERCETIN BASED NANO FORMULATION IN COMBATING HUMAN METAPNEUMOVIRUS INFECTIONS
    (Elsevier B.V, 2025) Veluswamy Bhuvaneshwari; Ramasamy Amsaveni; Department of Biotechnology; Veluswamy Bhuvaneshwari
    Human Metapneumovirus (hMPV) is a significant respiratory pathogen, particularly affecting children, the elderly, and immunocompromised individuals. Despite its clinical impact, there are currently no approved vaccines or specific antiviral treatments for hMPV, necessitating the exploration of novel therapeutic strategies. Quercetin, a naturally occurring flavonoid with well-documented antioxidant, anti-inflammatory, and antiviral properties, has shown promising potential in combating hMPV infections. However, its poor bioavailability limits its therapeutic efficacy. Recent advancements in nanotechnology offer a solution through quercetin-based nanoformulations, which enhance its solubility, stability, and bioavailability, thereby improving its antiviral potency. Molecular docking studies have demonstrated strong interactions between quercetin and the hMPV matrix protein, suggesting its role in inhibiting viral replication. Additionally, quercetin modulates oxidative stress and inflammatory responses by suppressing key pathways such as NF-κB and IRF-3, reducing lung damage associated with hMPV infections. In vitro and in vivo studies indicate that quercetin-loaded nanoparticles effectively decrease viral titers and inflammatory markers. Given its natural origin, safety profile, and therapeutic potential, quercetin-based nanoformulations emerge as a promising candidate for hMPV treatment. Further clinical trials are required to validate their efficacy and optimize formulations for potential clinical application.